FILTERS:
pvalue:1.0
Region for Gene 2RSSE.1
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This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region
Search region overview
Search region location CHROMOSOME_II:15,266,378-15,268,375 (+) (1998 bp)
Assembly C.elegans, Ensembl v45 (WS170)
WormBase ID 2RSSE.1
Modules
(Co-occurring motif patterns)
No annotation-based modules were found.
No 'de novo' modules exist in this database.

Genomic Context: C.elegans genome assembly from Jan 2007. (UCSC ce4, WS170, Ensembl v45)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

UCSC Genome Browser Image    
  • The first track shows the location of the search region in red.
  • The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
WormBase ID 2RSSE.1
Gene location CHROMOSOME_II: 15,268,376-15,273,209 (+) (4,834 bp)
Distance from the region's midpoint to TSS -998
The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
There are no 'de novo' patterns to show.
There are no (TRANSFAC) annotation-based patterns to show.
There are no (JASPAR) annotation-based patterns to show.

UCSC Genome Browser Image
Click on the image to view this region at UCSC.
    This image uses the C.elegans genome assembly from Jan 2007. (UCSC ce4, WS170, Ensembl v45) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:
  • The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.
  • The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.
  • Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.
  • The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)
  • Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 1.0
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 38 out of 38 atomic motifs.

Group(s)
crtCele#(name) [p-value]
Motif
craCele#
Discovery
p-value
Location Width (+)motif (-)motif
0 annotated groups

0 'de novo' group(s)
1 5.84E-01 CHROMOSOME_II:15,266,445-15,266,458 14  Seq Logo
TACnAmTAATmTTr
Seq Logo
yAAkATTAkTnGTA
0 annotated groups

0 'de novo' group(s)
2 6.52E-01 CHROMOSOME_II:15,266,451-15,266,464 14  Seq Logo
yAAkATTAGTCTTA
Seq Logo
TAAGACTAATmTTr
0 annotated groups

0 'de novo' group(s)
3 8.91E-01 CHROMOSOME_II:15,266,503-15,266,514 12  Seq Logo
AysnCTAATmTT
Seq Logo
AAkATTAGnwrT
0 annotated groups

0 'de novo' group(s)
4 8.66E-01 CHROMOSOME_II:15,266,540-15,266,553 14  Seq Logo
CwnTAwyyGTGAwA
Seq Logo
TsTCACrrsTAnsG
1 annotated group(s):
30003 (15492775-EARLY-1) [1.26E-05]

3 'de novo' group(s)
4, 77, 566
5 7.53E-01 CHROMOSOME_II:15,266,582-15,266,595 14  Seq Logo
AmAnTCTGCGTCkC
Seq Logo
GmGACGCAGAnTkT
0 annotated groups

0 'de novo' group(s)
6 7.56E-01 CHROMOSOME_II:15,266,608-15,266,624 17  Seq Logo
AnAnkCnTACTGGTTTs
Seq Logo
wAAACCAGTAnGmnTnT
0 annotated groups

1 'de novo' group(s)
73
7 2.24E-01 CHROMOSOME_II:15,266,631-15,266,638 8  Seq Logo
CCGCCAAC
Seq Logo
GTTGGCGG
0 annotated groups

2 'de novo' group(s)
175, 1156
9 7.12E-01 CHROMOSOME_II:15,266,709-15,266,720 12  Seq Logo
nACGAGGCGAGC
Seq Logo
GCTCGCCTCGTn
0 annotated groups

2 'de novo' group(s)
175, 1156
8 9.21E-01 CHROMOSOME_II:15,266,710-15,266,723 14  Seq Logo
mCGmrGCGCnnyGC
Seq Logo
GCrnnGCGCykCGk
0 annotated groups

0 'de novo' group(s)
10 1.40E-01 CHROMOSOME_II:15,266,719-15,266,726 8  Seq Logo
CCCGCCAA
Seq Logo
TTGGCGGG
0 annotated groups

0 'de novo' group(s)
11 8.58E-01 CHROMOSOME_II:15,266,737-15,266,750 14  Seq Logo
TACnAAArATATCA
Seq Logo
TGATATyTTTnGTA
0 annotated groups

0 'de novo' group(s)
12 9.56E-01 CHROMOSOME_II:15,267,196-15,267,207 12  Seq Logo
AGyTGGCGGGTA
Seq Logo
TACCCGCCArCT
0 annotated groups

0 'de novo' group(s)
13 1.99E-01 CHROMOSOME_II:15,267,399-15,267,414 16  Seq Logo
yATAATTACTTAATTA
Seq Logo
TAATTAAGTAATTATr
2 annotated group(s):
40066 (Egr-1) [5.07E-06]
50073 (RREB-1) [1.71E-05]

2 'de novo' group(s)
642, 3118
14 8.89E-01 CHROMOSOME_II:15,267,438-15,267,457 20  Seq Logo
GnrnnACmACCATsACAACn
Seq Logo
nGTTGTwATGGTkGTnnynC
1 annotated group(s):
50062 (NRF-2) [8.71E-05]

0 'de novo' group(s)
15 6.95E-01 CHROMOSOME_II:15,267,484-15,267,495 12  Seq Logo
nTnCTTCGTCGT
Seq Logo
ACGACGAAGnAn
0 annotated groups

3 'de novo' group(s)
343, 3053, 1849
16 9.42E-01 CHROMOSOME_II:15,267,556-15,267,569 14  Seq Logo
AGATTAGTGGTAGC
Seq Logo
GCTACCACTAATCT
1 annotated group(s):
40167 (PPAR-alpha) [1.52E-06]

0 'de novo' group(s)
17 8.27E-01 CHROMOSOME_II:15,267,829-15,267,842 14  Seq Logo
AnArkyATACnGsT
Seq Logo
AwCnGTATrmyTnT
0 annotated groups

0 'de novo' group(s)
18 8.49E-01 CHROMOSOME_II:15,267,883-15,267,898 16  Seq Logo
AnnnTGGTGGTAATkG
Seq Logo
CmATTACCACCAnnnT
0 annotated groups

0 'de novo' group(s)
19 9.39E-01 CHROMOSOME_II:15,268,022-15,268,033 12  Seq Logo
knTTAGTGGTwk
Seq Logo
msACCACTAAnm
2 annotated group(s):
50101 (c-REL) [5.63E-05]
50107 (p65) [9.42E-05]

0 'de novo' group(s)
20 7.60E-02 CHROMOSOME_II:15,268,102-15,268,118 17  Seq Logo
TnCAGTTGGCGGGTATT
Seq Logo
AATACCCGCCAACTGnA
0 annotated groups

2 'de novo' group(s)
35, 64
21 2.18E-01 CHROMOSOME_II:15,268,117-15,268,146 30  Seq Logo
TTCCAAGATTAGTGGTA...
Seq Logo
AnGAGGATrCAGCTACC...
0 annotated groups

0 'de novo' group(s)
22 5.50E-01 CHROMOSOME_II:15,268,154-15,268,165 12  Seq Logo
GCAnCACCATCA
Seq Logo
TGATGGTGnTGC
1 annotated group(s):
40167 (PPAR-alpha) [4.39E-06]

0 'de novo' group(s)
23 6.74E-01 CHROMOSOME_II:15,268,161-15,268,184 24  Seq Logo
CnyCrCCrCCACsACsA...
Seq Logo
nTwGTwGTwGTwGTGGy...
1 annotated group(s):
40167 (PPAR-alpha) [4.39E-06]

4 'de novo' group(s)
43, 459, 795, 1716
25 6.66E-01 CHROMOSOME_II:15,268,178-15,268,194 17  Seq Logo
CCrCCACGACGACGnCn
Seq Logo
nGnCGTCGTCGTGGyGG
1 annotated group(s):
40167 (PPAR-alpha) [4.39E-06]

1 'de novo' group(s)
795
24 4.74E-01 CHROMOSOME_II:15,268,181-15,268,192 12  Seq Logo
CCGCCnCGACGm
Seq Logo
kCGTCGnGGCGG
0 annotated groups

1 'de novo' group(s)
65
26 6.42E-01 CHROMOSOME_II:15,268,191-15,268,202 12  Seq Logo
GCnCGmCTCGTn
Seq Logo
nACGAGkCGnGC
0 annotated groups

0 'de novo' group(s)
27 9.20E-01 CHROMOSOME_II:15,268,205-15,268,224 20  Seq Logo
GTCGCCGCAGCAnCAnCAnC
Seq Logo
GnTGnTGnTGCTGCGGCGAC
0 annotated groups

2 'de novo' group(s)
69, 293
28 7.63E-01 CHROMOSOME_II:15,268,224-15,268,237 14  Seq Logo
CmCCATCAkCmnCG
Seq Logo
CGnkGmTGATGGkG
0 annotated groups

6 'de novo' group(s)
7, 91, 578, 640, 1486, 2478
29 7.48E-01 CHROMOSOME_II:15,268,232-15,268,259 28  Seq Logo
nCCGksmrTCACGACGw...
Seq Logo
TkrArACGACGsCGTCG...
3 annotated group(s):
40217 (ZID) [4.05E-06]
40117 (LXR-alpha) [7.38E-06]
40167 (PPAR-alpha) [8.56E-06]

2 'de novo' group(s)
24, 96
30 8.48E-01 CHROMOSOME_II:15,268,284-15,268,300 17  Seq Logo
nynCCmCCnyCwCCACC
Seq Logo
GGTGGsGrnGGkGGnrn
5 annotated group(s):
40092 (HIF-1) [6.63E-07]
40115 (Lmo2) [1.26E-06]
40167 (PPAR-alpha) [8.56E-06]
...


15 'de novo' group(s)
7, 11, 16, 91, 578, 624, 762, 804, 1019, 1486, 1541, 2478, 2713, 2809, 1817
31 4.17E-01 CHROMOSOME_II:15,268,298-15,268,366 69  Seq Logo
nCCGCCrCsACGACGAC...
Seq Logo
GCkrCGCnGnGGnTGnT...
2 annotated group(s):
40092 (HIF-1) [6.63E-07]
50007 (Androgen) [9.48E-05]

5 'de novo' group(s)
16, 91, 762, 1541, 2713
32 4.59E-01 CHROMOSOME_II:15,268,333-15,268,346 14  Seq Logo
CrCkkCGCCGCnGC
Seq Logo
GCnGCGGCGmmGyG
1 annotated group(s):
40092 (HIF-1) [6.63E-07]

2 'de novo' group(s)
91, 762
33 5.24E-01 CHROMOSOME_II:15,268,335-15,268,344 10  Seq Logo
CGkCGCAGCG
Seq Logo
CGCTGCGmCG
1 annotated group(s):
40092 (HIF-1) [6.63E-07]

3 'de novo' group(s)
91, 762, 1541
34 8.12E-02 CHROMOSOME_II:15,268,335-15,268,346 12  Seq Logo
CGTCGCCGCAGC
Seq Logo
GCTGCGGCGACG
1 annotated group(s):
40092 (HIF-1) [6.63E-07]

3 'de novo' group(s)
91, 762, 1541
35 1.95E-01 CHROMOSOME_II:15,268,335-15,268,348 14  Seq Logo
CGTCGCCGCAGCAC
Seq Logo
GTGCTGCGGCGACG
0 annotated groups

0 'de novo' group(s)
39 6.97E-02 CHROMOSOME_II:15,268,340-15,268,349 10  Seq Logo
CCGCAGCACC
Seq Logo
GGTGCTGCGG
1 annotated group(s):
50091 (Tal1beta-E47S) [8.78E-05]

2 'de novo' group(s)
400, 1282
41 4.52E-01 CHROMOSOME_II:15,268,360-15,268,373 14  Seq Logo
GCmnCGkCGCAGCG
Seq Logo
CGCTGCGmCGnkGC
0 annotated groups

2 'de novo' group(s)
400, 924
43 3.16E-01 CHROMOSOME_II:15,268,361-15,268,375 15  Seq Logo
CrTCGTCGTrGCGGC
Seq Logo
GCCGCyACGACGAyG

Questions or comments: cisred@bcgsc.ca