cisRED: cis-regulatory element database

cisRED > Human 9 > gene. ENSG00000001630

Region for Gene ENSG00000001630 (HGNC Symbol: CYP51A1)

This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region

Search region overview
Search region location	chr7:91,601,747-91,604,931 (-) (3185 bp)
Assembly	Human, Ensembl v40 (NCBI 36)
Gene name	CYP51A1
Ensembl gene ID	ENSG00000001630
Gene description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM). [Source:Uniprot/SWISSPROT;Acc:Q16850]
Gene description source	HGNC Symbol
Modules (Co-occurring motif patterns)	29 annotation-based module(s) No 'de novo' modules exist in this database.

Genomic Context: Human genome assembly from Mar 2006. (UCSC hg18, NCBI 36, Ensembl v40)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

The first track shows the location of the search region in red.
The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
Ensembl ID	ENSG00000001630 (CYP51A1)
RefSeq ID	NM_000786
Gene description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM). [Source:Uniprot/SWISSPROT;Acc:Q16850]
Gene type	protein_coding
Gene location	chr7: 91,579,402-91,601,946 (-) (22,545 bp)
Distance from the region's midpoint to TSS	-1393

The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
Note: This search region contains more patterns than are displayed in this UCSC genome browser image.
There are no 'de novo' patterns to show.
Only the top 20 ranked (TRANSFAC) annotation-based patterns are shown.
There are no (JASPAR) annotation-based patterns to show.

Click on the image to view this region at UCSC.

This image uses the Human genome assembly from Mar 2006. (UCSC hg18, NCBI 36, Ensembl v40) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:

The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.

The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.

Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.

The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)

Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 0.1
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 38 out of 38 atomic motifs.

Group(s) crtHsap#(name) [p-value]	Motif craHsap#	Discovery p-value	Location	Width	(+)motif	(-)motif
3 annotated group(s): 40117 (LXR-alpha) [4.76E-04] 40154 (Pax-5) [7.74E-04] 40003 (AhR) [8.26E-04]	280	5.01E-04	chr7:91,601,755-91,601,764	10	GTGGCGCGCG	CGCGCGCCAC
3 annotated group(s): 40117 (LXR-alpha) [4.76E-04] 40154 (Pax-5) [7.74E-04] 40003 (AhR) [8.26E-04]	289	5.01E-04	chr7:91,601,755-91,601,762	8	GGCGCGCG	CGCGCGCC
4 annotated group(s): 40117 (LXR-alpha) [4.76E-04] 40003 (AhR) [5.08E-04] 40154 (Pax-5) [7.74E-04] ...	307	5.01E-04	chr7:91,601,755-91,601,760	6	CGCGCG	CGCGCG
7 annotated group(s): 40048 (CREB) [2.14E-04] 40017 (ATF) [4.04E-04] 40048 (CREB) [4.80E-04] ...	266	5.01E-04	chr7:91,601,770-91,601,775	6	TGACGC	GCGTCA
6 annotated group(s): 40048 (CREB) [2.14E-04] 40017 (ATF) [4.04E-04] 40048 (CREB) [4.80E-04] ...	258	5.01E-04	chr7:91,601,771-91,601,776	6	GTGACG	CGTCAC
4 annotated group(s): 40003 (AhR) [3.67E-05] 40154 (Pax-5) [4.23E-04] 40003 (AhR) [5.21E-04] ...	240	5.01E-04	chr7:91,601,800-91,601,811	12	rGGGGCGTGGCC	GGCCACGCCCCy
3 annotated group(s): 40003 (AhR) [3.67E-05] 40154 (Pax-5) [4.23E-04] 40003 (AhR) [7.89E-04]	247	5.01E-04	chr7:91,601,801-91,601,810	10	GGGGCGkGGC	GCCmCGCCCC
0 annotated groups	233	3.00E-03	chr7:91,601,889-91,601,900	12	GCCCCGCmCCnn	nnGGkGCGGGGC
1 annotated group(s): 50007 (Androgen) [6.48E-04]	227	3.93E-02	chr7:91,602,043-91,602,054	12	CACmkCrCGCGC	GCGCGyGmkGTG
1 annotated group(s): 50066 (PPARgamma) [6.16E-04]	189	3.57E-02	chr7:91,602,072-91,602,084	13	yGAGATCACCTCA	TGAGGTGATCTCr
2 annotated group(s): 50066 (PPARgamma) [6.16E-04] 40168 (PTF1-beta) [9.86E-04]	217	5.01E-04	chr7:91,602,072-91,602,083	12	GAGATCACCTCA	TGAGGTGATCTC
1 annotated group(s): 50066 (PPARgamma) [1.75E-04]	201	5.01E-04	chr7:91,602,073-91,602,084	12	CGAGATCACCTC	GAGGTGATCTCG
1 annotated group(s): 50066 (PPARgamma) [1.75E-04]	182	5.01E-04	chr7:91,602,074-91,602,085	12	CCGAGATCACCT	AGGTGATCTCGG
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40168 (PTF1-beta) [9.86E-04]	209	5.01E-04	chr7:91,602,074-91,602,083	10	GAGATCACCT	AGGTGATCTC
1 annotated group(s): 50066 (PPARgamma) [1.75E-04]	169	5.01E-04	chr7:91,602,075-91,602,086	12	GCCGAGATCACC	GGTGATCTCGGC
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	174	5.01E-04	chr7:91,602,076-91,602,085	10	CCGAGATCAC	GTGATCTCGG
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	150	5.01E-04	chr7:91,602,078-91,602,089	12	TAGGCCGAGATC	GATCTCGGCCTA
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	163	5.01E-04	chr7:91,602,078-91,602,087	10	GGCCGAGATC	GATCTCGGCC
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	156	5.01E-04	chr7:91,602,079-91,602,088	10	AGGCCGAGAT	ATCTCGGCCT
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	131	5.01E-04	chr7:91,602,080-91,602,091	12	yATAGGCCGAGA	TCTCGGCCTATr
2 annotated group(s): 50066 (PPARgamma) [1.75E-04] 40053 (DEAF-1) [6.10E-04]	140	5.01E-04	chr7:91,602,080-91,602,089	10	TAGGCCGAGA	TCTCGGCCTA
1 annotated group(s): 40053 (DEAF-1) [6.10E-04]	121	5.01E-04	chr7:91,602,082-91,602,093	12	GAyrTmGGCCkA	TmGGCCkAyrTC
2 annotated group(s): 40106 (HTF) [5.27E-04] 40053 (DEAF-1) [6.10E-04]	112	5.01E-04	chr7:91,602,084-91,602,093	10	GATsTCGGCC	GGCCGAwATC
2 annotated group(s): 40106 (HTF) [5.27E-04] 40053 (DEAF-1) [6.10E-04]	101	5.01E-04	chr7:91,602,086-91,602,097	12	AsGyGAyrTmGG	CCkAyrTCrCwT
2 annotated group(s): 40106 (HTF) [5.27E-04] 40053 (DEAF-1) [6.10E-04]	94	5.01E-04	chr7:91,602,088-91,602,099	12	TGACGCsACATA	TATGTwGCGTCA
3 annotated group(s): 40017 (ATF) [4.86E-04] 40106 (HTF) [5.27E-04] 40053 (DEAF-1) [6.10E-04]	78	5.01E-04	chr7:91,602,089-91,602,100	12	CTGACGCsAyrT	AyrTwGCGTCAG
6 annotated group(s): 40020 (ATF4) [1.25E-04] 40048 (CREB) [3.23E-04] 40048 (CREB) [3.99E-04] ...	76	5.01E-04	chr7:91,602,091-91,602,100	10	CTGAsGyGAT	ATCrCwTCAG
8 annotated group(s): 40020 (ATF4) [1.25E-04] 40048 (CREB) [1.30E-04] 40048 (CREB) [3.23E-04] ...	74	5.01E-04	chr7:91,602,092-91,602,101	10	GCTGACGCsA	TwGCGTCAGC
9 annotated group(s): 40020 (ATF4) [1.25E-04] 40048 (CREB) [1.30E-04] 40048 (CREB) [3.23E-04] ...	86	5.01E-04	chr7:91,602,092-91,602,099	8	TGACGCsA	TwGCGTCA
9 annotated group(s): 40048 (CREB) [1.30E-04] 50018 (CREB) [1.40E-04] 40048 (CREB) [3.23E-04] ...	70	5.01E-04	chr7:91,602,093-91,602,102	10	CGCTGACGCs	wGCGTCAGCG
5 annotated group(s): 40154 (Pax-5) [1.27E-06] 40003 (AhR) [8.99E-05] 50014 (Bsap) [1.12E-04] ...	69	3.22E-02	chr7:91,602,108-91,602,119	12	GCTGACGCCmCA	TGkGGCGTCAGC
2 annotated group(s): 40092 (HIF-1) [1.80E-04] 40106 (HTF) [4.64E-04]	62	5.01E-04	chr7:91,602,186-91,602,191	6	CGTGGC	GCCACG
2 annotated group(s): 40106 (HTF) [4.64E-04] 40021 (ATF6) [7.38E-04]	58	6.43E-02	chr7:91,602,187-91,602,198	12	CsCAmGAsGTGG	CCACwTCkTGwG
8 annotated group(s): 40048 (CREB) [9.64E-05] 40012 (AP-1) [1.17E-04] 40020 (ATF4) [2.58E-04] ...	55	6.09E-04	chr7:91,602,281-91,602,299	19	GGTGAyCTCrsCkTAyGTG	CACrTAmGwyGAGrTCACC
2 annotated group(s): 50091 (Tal1beta-E47S) [2.55E-04] 40076 (FOXC2) [8.36E-04]	53	9.91E-02	chr7:91,602,357-91,602,366	10	TACATTTrTT	AAyAAATGTA
0 annotated groups	50	6.55E-02	chr7:91,602,498-91,602,510	13	AGCTTCwGAATCT	AGATTCsGAAGCT
2 annotated group(s): 40012 (AP-1) [2.45E-04] 40004 (AIRE) [2.63E-04]	48	9.90E-02	chr7:91,603,020-91,603,031	12	TTAmATTTGkTA	TAmCAAATkTAA
4 annotated group(s): 40038 (Cdc5) [1.04E-04] 40043 (COMP1) [2.94E-04] 40039 (Cdx-2) [8.49E-04] ...	46	6.58E-02	chr7:91,604,728-91,604,735	8	TTAAATAA	TTATTTAA