FILTERS:
pvalue:0.1
Region for Gene ENSMUSG00000000317 (MGI Symbol: Bcl6b)
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This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region
Search region overview
Search region location chr11:70,043,062-70,044,761 (-) (1700 bp)
Assembly Mouse, Ensembl v47 (NCBI m37)
Gene name Bcl6b
Ensembl gene ID ENSMUSG00000000317
Gene description B-cell CLL/lymphoma 6, member B [Source:MarkerSymbol;Acc:MGI:1278332]
Gene description source MGI Symbol
Modules
(Co-occurring motif patterns)
No annotation-based modules were found.
No 'de novo' modules exist in this database.

Genomic Context: Mouse genome assembly from July 2007. (UCSC mm9, NCBI m37, Ensembl v47)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

UCSC Genome Browser Image    
  • The first track shows the location of the search region in red.
  • The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
Ensembl ID ENSMUSG00000000317 (Bcl6b)
Ensembl Transcript ID ENSMUST00000000326
Gene description B-cell CLL/lymphoma 6, member B [Source:MarkerSymbol;Acc:MGI:1278332]
Gene type protein_coding
Gene location chr11: 70,305,702-70,311,333 (-) (5,632 bp)
Distance from the region's midpoint to TSS 267422
The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
There are no 'de novo' patterns to show.
There are no (TRANSFAC) annotation-based patterns to show.
There are no (JASPAR) annotation-based patterns to show.

UCSC Genome Browser Image
Click on the image to view this region at UCSC.
    This image uses the Mouse genome assembly from July 2007. (UCSC mm9, NCBI m37, Ensembl v47) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:
  • The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.
  • The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.
  • Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.
  • The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)
  • Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 0.1
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 19 out of 19 atomic motifs.

Group(s)
crtMmus#(name) [p-value]
Motif
craMmus#
Discovery
p-value
Location Width (+)motif (-)motif
0 annotated groups 1236 2.67E-02 chr11:70,043,178-70,043,186 9  Seq Logo
yGATTTCTm
Seq Logo
kAGAAATCr
0 annotated groups 1210 6.09E-02 chr11:70,043,180-70,043,189 10  Seq Logo
ATATGATTTC
Seq Logo
GAAATCATAT
2 annotated group(s):
200143 (Pax-5) [2.06E-04]
200261 (Olf-1) [7.11E-04]
1176 8.33E-02 chr11:70,043,216-70,043,227 12  Seq Logo
CCCCTGCAGGAC
Seq Logo
GTCCTGCAGGGG
0 annotated groups 1153 8.33E-02 chr11:70,043,288-70,043,300 13  Seq Logo
ATCCCGGCCAGAT
Seq Logo
ATCTGGCCGGGAT
1 annotated group(s):
4000 (FoxA1) [7.27E-04]
1114 8.33E-02 chr11:70,043,336-70,043,353 18  Seq Logo
GAAGGAAGGATACAGACC
Seq Logo
GGTCTGTATCCTTCCTTC
0 annotated groups 1108 2.42E-02 chr11:70,043,346-70,043,355 10  Seq Logo
AGGAAGGAAG
Seq Logo
CTTCCTTCCT
8 annotated group(s):
200938 (E2F-1) [1.85E-04]
200803 (DP-1) [1.92E-04]
200803 (DP-1) [2.95E-04]
...
1080 8.33E-02 chr11:70,043,378-70,043,389 12  Seq Logo
CCCCGCCCnGGG
Seq Logo
CCCnGGGCGGGG
3 annotated group(s):
200720 (CAC-binding_protein) [8.22E-04]
200649 (MAZ) [8.84E-04]
200807 (Egr-1) [8.88E-04]
1054 8.20E-03 chr11:70,043,381-70,043,393 13  Seq Logo
GAGACCCCGCCCC
Seq Logo
GGGGCGGGGTCTC
2 annotated group(s):
200729 (Cdx-2) [4.53E-04]
200133 (POU3F1) [8.24E-04]
1027 8.33E-02 chr11:70,043,475-70,043,486 12  Seq Logo
AATTCyAATATC
Seq Logo
GATATTrGAATT
4 annotated group(s):
200489 (Nkx6-2) [5.25E-05]
200446 (Spz1) [4.76E-04]
200395 (HOXA3) [5.91E-04]
...
1019 4.49E-02 chr11:70,043,513-70,043,518 6  Seq Logo
ATATTA
Seq Logo
TAATAT
3 annotated group(s):
4000 (FoxA1) [3.83E-05]
200531 (NERF-1a) [2.89E-04]
4000 (FoxA1) [4.25E-04]
1002 3.44E-03 chr11:70,043,649-70,043,660 12  Seq Logo
TATTTTGTTTsG
Seq Logo
CwAAACAAAATA
1 annotated group(s):
200011 (Evi-1) [6.76E-04]
980 8.33E-02 chr11:70,043,803-70,043,815 13  Seq Logo
AGAAATCATATCC
Seq Logo
GGATATGATTTCT
0 annotated groups 873 8.33E-02 chr11:70,043,866-70,043,877 12  Seq Logo
CTCCTCGAGGGG
Seq Logo
CCCCTCGAGGAG
3 annotated group(s):
201001 (DEAF-1) [6.74E-05]
201001 (DEAF-1) [4.81E-04]
200665 (Sp3) [8.19E-04]
846 8.33E-02 chr11:70,043,887-70,043,899 13  Seq Logo
CCCCrCCCnGGGC
Seq Logo
GCCCnGGGyGGGG
1 annotated group(s):
201001 (DEAF-1) [7.89E-04]
810 8.33E-02 chr11:70,043,918-70,043,929 12  Seq Logo
GACsCCkGsGTC
Seq Logo
GACwCmGGwGTC
2 annotated group(s):
200800 (AP-2) [1.78E-04]
200800 (AP-2) [6.65E-04]
786 8.33E-02 chr11:70,044,043-70,044,053 11  Seq Logo
CCGACGGGCGG
Seq Logo
CCGCCCGTCGG
4 annotated group(s):
200242 (PPAR-alpha) [2.21E-04]
200032 (c-Ets-1) [4.19E-04]
200467 (Roaz) [4.99E-04]
...
755 8.33E-02 chr11:70,044,070-70,044,089 20  Seq Logo
GCTGGACCCCGGCGTCCCsC
Seq Logo
GwGGGACGCCGGGGTCCAGC
0 annotated groups 723 8.33E-02 chr11:70,044,122-70,044,137 16  Seq Logo
CCCCTCGTGGAAGGAG
Seq Logo
CTCCTTCCACGAGGGG
5 annotated group(s):
200145 (POU3F2) [1.30E-04]
200622 (C-EBPgamma) [2.71E-04]
200098 (Pax-2) [3.76E-04]
...
679 5.71E-02 chr11:70,044,466-70,044,471 6  Seq Logo
AAAATT
Seq Logo
AATTTT

Questions or comments: cisred@bcgsc.ca