FILTERS:
pvalue:0.25
Region for Gene ENSRNOG00000000456 (Uniprot/SWISSPROT: Psmb8)
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This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region
Search region overview
Search region location chr20:4,789,229-4,791,866 (-) (2638 bp)
Assembly Rat, Ensembl v22 (RGSC 3.1)
Gene name Psmb8
Ensembl gene ID ENSRNOG00000000456
Gene description source Uniprot/SWISSPROT
Modules
(Co-occurring motif patterns)
No annotation-based modules were found.
No 'de novo' modules were found.

Genomic Context: Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

UCSC Genome Browser Image    
  • The first track shows the location of the search region in red.
  • The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
Ensembl ID ENSRNOG00000000456 (Psmb8)
Ensembl Transcript ID ENSRNOT00000000528
Gene location chr20: 4,786,491-4,789,400 (-) (2,910 bp)
Distance from the region's midpoint to TSS -1147
The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
There are no 'de novo' patterns to show.
There are no (TRANSFAC) annotation-based patterns to show.
There are no (JASPAR) annotation-based patterns to show.

UCSC Genome Browser Image
Click on the image to view this region at UCSC.
    This image uses the Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:
  • The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.
  • The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.
  • Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.
  • The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)
  • Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 0.25
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 31 out of 31 atomic motifs.

Group(s)
crtRnor#(name) [p-value]
Motif
craRnor#
Discovery
p-value
Location Width (+)motif (-)motif
0 annotated groups

1 'de novo' group(s)
9045
25440 1.33E-01 chr20:4,789,441-4,789,452 12  Seq Logo
TCGCTTTCACTT
Seq Logo
AAGTGAAAGCGA
0 annotated groups

1 'de novo' group(s)
9045
25388 1.33E-01 chr20:4,789,442-4,789,453 12  Seq Logo
TTCGCTTTCACT
Seq Logo
AGTGAAAGCGAA
0 annotated groups

1 'de novo' group(s)
9882
25695 5.49E-03 chr20:4,789,442-4,789,451 10  Seq Logo
CGCTTTCACT
Seq Logo
AGTGAAAGCG
0 annotated groups

1 'de novo' group(s)
9045
25271 1.33E-01 chr20:4,789,443-4,789,454 12  Seq Logo
TTTCGCTTTCAC
Seq Logo
GTGAAAGCGAAA
0 annotated groups

0 'de novo' group(s)
25597 5.49E-03 chr20:4,789,443-4,789,452 10  Seq Logo
TCGCTTTCAC
Seq Logo
GTGAAAGCGA
0 annotated groups

0 'de novo' group(s)
25787 5.49E-03 chr20:4,789,443-4,789,450 8  Seq Logo
GCTTTCAC
Seq Logo
GTGAAAGC
0 annotated groups

1 'de novo' group(s)
9045
25101 1.33E-01 chr20:4,789,444-4,789,455 12  Seq Logo
CTTTCGCTTTCA
Seq Logo
TGAAAGCGAAAG
0 annotated groups

0 'de novo' group(s)
25223 8.33E-03 chr20:4,789,445-4,789,454 10  Seq Logo
TTTCGCTTTC
Seq Logo
GAAAGCGAAA
0 annotated groups

0 'de novo' group(s)
25541 5.49E-03 chr20:4,789,445-4,789,452 8  Seq Logo
TCGCTTTC
Seq Logo
GAAAGCGA
0 annotated groups

0 'de novo' group(s)
25740 5.49E-03 chr20:4,789,445-4,789,450 6  Seq Logo
GCTTTC
Seq Logo
GAAAGC
0 annotated groups

1 'de novo' group(s)
14155
25837 7.71E-02 chr20:4,789,445-4,789,464 20  Seq Logo
GkyGTGTGACGTCrrCAkTT
Seq Logo
AAmTGyyGACGTCACACrmC
0 annotated groups

0 'de novo' group(s)
25058 8.33E-03 chr20:4,789,446-4,789,455 10  Seq Logo
CTTTCGCTTT
Seq Logo
AAAGCGAAAG
0 annotated groups

0 'de novo' group(s)
25337 1.13E-03 chr20:4,789,446-4,789,453 8  Seq Logo
TTCGCTTT
Seq Logo
AAAGCGAA
0 annotated groups

1 'de novo' group(s)
7041
25644 5.49E-03 chr20:4,789,446-4,789,451 6  Seq Logo
CGCTTT
Seq Logo
AAAGCG
0 annotated groups

0 'de novo' group(s)
25012 5.49E-03 chr20:4,789,447-4,789,456 10  Seq Logo
GCTTTCGCTT
Seq Logo
AAGCGAAAGC
0 annotated groups

0 'de novo' group(s)
25186 1.13E-03 chr20:4,789,447-4,789,454 8  Seq Logo
TTTCGCTT
Seq Logo
AAGCGAAA
0 annotated groups

1 'de novo' group(s)
5813
25488 5.49E-03 chr20:4,789,447-4,789,452 6  Seq Logo
TCGCTT
Seq Logo
AAGCGA
0 annotated groups

0 'de novo' group(s)
24921 5.49E-03 chr20:4,789,448-4,789,457 10  Seq Logo
GGCTTTCGCT
Seq Logo
AGCGAAAGCC
0 annotated groups

0 'de novo' group(s)
25142 5.49E-03 chr20:4,789,448-4,789,455 8  Seq Logo
CTTTCGCT
Seq Logo
AGCGAAAG
0 annotated groups

0 'de novo' group(s)
24966 5.49E-03 chr20:4,789,449-4,789,456 8  Seq Logo
GCTTTCGC
Seq Logo
GCGAAAGC
0 annotated groups

0 'de novo' group(s)
24875 5.49E-03 chr20:4,789,450-4,789,457 8  Seq Logo
GGCTTTCG
Seq Logo
CGAAAGCC
0 annotated groups

0 'de novo' group(s)
24850 2.20E-01 chr20:4,789,510-4,789,521 12  Seq Logo
wGGGCTCTACTC
Seq Logo
GAGTAGAGCCCs
0 annotated groups

0 'de novo' group(s)
24821 2.37E-01 chr20:4,789,800-4,789,811 12  Seq Logo
sTrCTGCCCCsA
Seq Logo
TwGGGGCAGyAw
0 annotated groups

1 'de novo' group(s)
5199
24785 2.04E-01 chr20:4,789,826-4,789,831 6  Seq Logo
ATAAAA
Seq Logo
TTTTAT
0 annotated groups

1 'de novo' group(s)
14155
24765 7.85E-02 chr20:4,790,122-4,790,144 23  Seq Logo
nCnsGnnGnGTGACGTC...
Seq Logo
ACTGyTGACGTCACnCn...
0 annotated groups

1 'de novo' group(s)
9045
24713 1.38E-02 chr20:4,790,178-4,790,190 13  Seq Logo
TGAAAGCGAAAGC
Seq Logo
GCTTTCGCTTTCA
0 annotated groups

1 'de novo' group(s)
2318
24666 7.04E-02 chr20:4,790,443-4,790,450 8  Seq Logo
TTTCACTT
Seq Logo
AAGTGAAA
0 annotated groups

1 'de novo' group(s)
7828
24619 2.23E-01 chr20:4,791,314-4,791,325 12  Seq Logo
rGGAAGTGrAAG
Seq Logo
CTTyCACTTCCy
0 annotated groups

0 'de novo' group(s)
24581 1.06E-01 chr20:4,791,457-4,791,468 12  Seq Logo
TACAGwwAGAGG
Seq Logo
CCTCTssCTGTA
0 annotated groups

0 'de novo' group(s)
24549 7.71E-02 chr20:4,791,763-4,791,777 15  Seq Logo
GGTCTTCCGAAGAAA
Seq Logo
TTTCTTCGGAAGACC
0 annotated groups

0 'de novo' group(s)
24506 7.20E-03 chr20:4,791,813-4,791,824 12  Seq Logo
wAAnnrAATATA
Seq Logo
TATATTynnTTs

Questions or comments: cisred@bcgsc.ca