FILTERS:
pvalue:0.25
Region for Gene ENSRNOG00000000632 (Uniprot/SWISSPROT: Cdc2)
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This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region
Search region overview
Search region location chr20:20,028,797-20,032,042 (+) (3246 bp)
Assembly Rat, Ensembl v22 (RGSC 3.1)
Gene name Cdc2
Ensembl gene ID ENSRNOG00000000632
Gene description source Uniprot/SWISSPROT
Modules
(Co-occurring motif patterns)
No annotation-based modules were found.
No 'de novo' modules were found.

Genomic Context: Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

UCSC Genome Browser Image    
  • The first track shows the location of the search region in red.
  • The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
Ensembl ID ENSRNOG00000000632 (Cdc2)
Ensembl Transcript ID ENSRNOT00000000783
Gene location chr20: 20,031,844-20,057,830 (+) (25,987 bp)
Distance from the region's midpoint to TSS -1423
The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
There are no 'de novo' patterns to show.
There are no (TRANSFAC) annotation-based patterns to show.
There are no (JASPAR) annotation-based patterns to show.

UCSC Genome Browser Image
Click on the image to view this region at UCSC.
    This image uses the Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:
  • The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.
  • The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.
  • Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.
  • The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)
  • Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 0.25
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 18 out of 18 atomic motifs.

Group(s)
crtRnor#(name) [p-value]
Motif
craRnor#
Discovery
p-value
Location Width (+)motif (-)motif
0 annotated groups

0 'de novo' group(s)
28276 5.49E-02 chr20:20,028,949-20,028,960 12  Seq Logo
GGCGCCCGCCCT
Seq Logo
AGGGCGGGCGCC
0 annotated groups

1 'de novo' group(s)
7911
28326 7.31E-02 chr20:20,029,097-20,029,109 13  Seq Logo
TCAATTTAACTCA
Seq Logo
TGAGTTAAATTGA
0 annotated groups

0 'de novo' group(s)
28368 1.16E-01 chr20:20,030,332-20,030,348 17  Seq Logo
TnCmTTTAACATwmAnn
Seq Logo
nnTksATGTTAAAkGnA
0 annotated groups

1 'de novo' group(s)
7337
28407 2.50E-02 chr20:20,030,388-20,030,400 13  Seq Logo
ATACATwATrwAn
Seq Logo
nTsyATsATGTAT
0 annotated groups

1 'de novo' group(s)
3276
28459 2.06E-01 chr20:20,030,439-20,030,445 7  Seq Logo
GGCGGGC
Seq Logo
GCCCGCC
0 annotated groups

1 'de novo' group(s)
13487
28497 1.16E-01 chr20:20,030,657-20,030,675 19  Seq Logo
CAATCnGrTAGCmCGTAGA
Seq Logo
TCTACGkGCTAyCnGATTG
0 annotated groups

1 'de novo' group(s)
13992
28533 1.30E-01 chr20:20,030,681-20,030,700 20  Seq Logo
yATGyywsTsTsTATATAwk
Seq Logo
msTATATAwAwAwsrrCATr
0 annotated groups

0 'de novo' group(s)
28563 1.15E-01 chr20:20,031,193-20,031,214 22  Seq Logo
CTnnwmATAATAAAnnT...
Seq Logo
AATnnAnnTTTATTATk...
0 annotated groups

0 'de novo' group(s)
28588 1.16E-01 chr20:20,031,273-20,031,292 20  Seq Logo
wnArkAATnTTTAAnATTnn
Seq Logo
nnAATnTTAAAnATTmyTns
0 annotated groups

1 'de novo' group(s)
8578
28620 2.41E-01 chr20:20,031,502-20,031,514 13  Seq Logo
CTAATCACTTTTA
Seq Logo
TAAAAGTGATTAG
0 annotated groups

1 'de novo' group(s)
1094
28653 2.50E-02 chr20:20,031,539-20,031,547 9  Seq Logo
ATTTwAAAT
Seq Logo
ATTTsAAAT
0 annotated groups

1 'de novo' group(s)
13226
28698 2.07E-03 chr20:20,031,660-20,031,679 20  Seq Logo
TCAGTTGGCGCCCGCCCTCC
Seq Logo
GGAGGGCGGGCGCCAACTGA
0 annotated groups

1 'de novo' group(s)
14663
28733 2.19E-01 chr20:20,031,705-20,031,725 21  Seq Logo
GskCCCTTTmGCGCksT...
Seq Logo
rCkCAwmGCGCkAAAGG...
0 annotated groups

1 'de novo' group(s)
12183
28777 2.47E-01 chr20:20,031,782-20,031,793 12  Seq Logo
TACrTrsAAkyk
Seq Logo
mrmTTwyAyGTA
0 annotated groups

1 'de novo' group(s)
3372
28816 2.41E-02 chr20:20,031,804-20,031,810 7  Seq Logo
CCCGGGA
Seq Logo
TCCCGGG
0 annotated groups

0 'de novo' group(s)
28851 2.50E-02 chr20:20,031,810-20,031,839 30  Seq Logo
GCCCTTTAGCGCGGTGA...
Seq Logo
AGCAGTTTCAAACTCAC...
0 annotated groups

1 'de novo' group(s)
6393
28896 2.33E-02 chr20:20,031,956-20,031,967 12  Seq Logo
GGGCGGGCkCCA
Seq Logo
TGGmGCCCGCCC
0 annotated groups

1 'de novo' group(s)
2463
28950 7.50E-03 chr20:20,031,985-20,031,992 8  Seq Logo
myCCGGGG
Seq Logo
CCCCGGrk

Questions or comments: cisred@bcgsc.ca