FILTERS:
pvalue:0.25
Region for Gene ENSRNOG00000000811 (Uniprot/SWISSPROT: Pkib)
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This page describes one promoter-based search region.

Page Contents

Overview
Genomic Context
Image of Motifs and Modules
Motifs Found in this Region
Search region overview
Search region location chr20:36,667,409-36,669,481 (+) (2073 bp)
Assembly Rat, Ensembl v22 (RGSC 3.1)
Gene name Pkib
Ensembl gene ID ENSRNOG00000000811
Gene description source Uniprot/SWISSPROT
Modules
(Co-occurring motif patterns)
No annotation-based modules were found.
No 'de novo' modules were found.

Genomic Context: Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22)

The image shown below was created to provide context for this search region by showing a 100000 bp span of the genome, centered on this search region.

UCSC Genome Browser Image    
  • The first track shows the location of the search region in red.
  • The last track shows known gene locations in this 100000 bp span of the genome.

This promoter-based search region is located close to a particular gene of interest, described in the table below. Click on the gene id to open a page at ensembl.org with more information about this gene.

Target gene used to create this search region
Ensembl ID ENSRNOG00000000811 (Pkib)
Ensembl Transcript ID ENSRNOT00000001075
Gene location chr20: 36,669,315-36,764,236 (+) (94,922 bp)
Distance from the region's midpoint to TSS -868
The distance from a cisred search region to a gene, is measured from the center of the search region to either the transcription termination site (TTS) or the transcription start site (TSS), whichever is closer.
A distance is negative if the TTS/TTS is downstream of the search region's center, relative to the gene's strand.
A distance is positive if the TTS/TTS is upstream of the search region's center, relative to the gene's strand.

A transcript's location is always reported relative to the positive strand.

Image of Motifs and Modules

The image shown below illustrates the location of the motifs and modules within this search region.
However, the number of modules in a region may exceed the genome browser's track limit. Thus, for each type of module (pattern), the text in the yellow box below indicates whether or not any modules of that type exist, and if so, whether or not all the modules of that type are displayed. (If it indicates that only the top 20 modules are displayed, this ranking is based on the number of instances of each module.)

User-specified filter settings do not affect the features displayed in the UCSC genome browser view.

About the patterns shown in this image:
There are no 'de novo' patterns to show.
There are no (TRANSFAC) annotation-based patterns to show.
There are no (JASPAR) annotation-based patterns to show.

UCSC Genome Browser Image
Click on the image to view this region at UCSC.
    This image uses the Rat genome assembly from Jun 2003. (UCSC rn3, RGSC 3.1, Ensembl v22) and contains a number of custom tracks followed by several UCSC tracks. The custom tracks show:
  • The long red and gray bar at the top shows the nominal 'search region' within which comparative genomics discovery methods were applied. Motif predictions were not made in coding exons and most types of repeats. In this database, the locations of masks applied to the search region are shown in gray.
  • The numbered brown blocks are 'atomic' motifs, i.e. conserved DNA sequence motifs that were identified by discovery methods and post-processing operations. Motifs are shaded to indicate the discovery p-value; a darker motif was more significant at the discovery stage.
  • Following the motif discovery stage, motifs were filtered by membership in co-occurring patterns, and patterns were ranked by genome-scale properties. Motifs instances that occur in highly-ranked putative regulatory modules may be more reliable predictions of functional genomic elements.
  • The connected sets of blue boxes are co-occurring patterns, i.e. putative regulatory modules. Modules are shaded to indicate the number of times that a pattern is found in the target genome; a darker module is associated with more search regions. An pattern is called either 'de novo' or annotation-based, depending on the type of groups that appear in the pattern. (see next point)
  • Before patterns (i.e. modules) can be identified from atomic motifs, groups of similar motifs must be found; modules are then identified as co-occurring 'group labels' that satisfy certain criteria. Such groups can be identified a) by annotating atomic motifs with known binding site resources from TRANSFAC, JASPAR or ORegAnno; or b) by 'de novo' clustering. Currently we show both types of patterns, but we consider annotation-based groups and patterns to be more reliable than 'de novo' groups and patterns. Work to improve genome-scale 'de novo' grouping is ongoing.

Motifs Found in this Region

The contents of the table below can be modified by changing your filter settings.
Currently, this table only contains motifs which:
+ have a discovery p-value < 0.25
+ were found using any of these algorithms: MotifSampler, Consensus.oops, Consensus.omops, Consensus.zmops, MEME.tcm, MEME.oops, MEME.zoops

Showing 18 out of 18 atomic motifs.

Group(s)
crtRnor#(name) [p-value]
Motif
craRnor#
Discovery
p-value
Location Width (+)motif (-)motif
0 annotated groups

1 'de novo' group(s)
15093
38818 1.47E-01 chr20:36,667,483-36,667,503 21  Seq Logo
AmCTACAkwTGmAmwyw...
Seq Logo
ynkrsrskTkCAsmTGT...
0 annotated groups

1 'de novo' group(s)
1034
38847 1.84E-01 chr20:36,667,551-36,667,560 10  Seq Logo
TCCCGCCCCC
Seq Logo
GGGGGCGGGA
0 annotated groups

0 'de novo' group(s)
38893 1.12E-01 chr20:36,667,604-36,667,631 28  Seq Logo
mmrmwwnkrwwrCAmTA...
Seq Logo
sTsCyAkTwCATAkTGy...
0 annotated groups

0 'de novo' group(s)
38924 2.45E-01 chr20:36,667,665-36,667,677 13  Seq Logo
nnAATATGCAAnn
Seq Logo
nnTTGCATATTnn
0 annotated groups

0 'de novo' group(s)
38953 1.18E-01 chr20:36,668,388-36,668,405 18  Seq Logo
nrTTwTAGwATmACTCwC
Seq Logo
GsGAGTkATsCTAsAAyn
0 annotated groups

1 'de novo' group(s)
15093
38985 9.08E-02 chr20:36,668,548-36,668,572 25  Seq Logo
rCTACmGTkGCACGTkC...
Seq Logo
TwCyykGkGmACGTGCm...
0 annotated groups

1 'de novo' group(s)
9645
39009 3.09E-03 chr20:36,668,799-36,668,810 12  Seq Logo
TTTTATTGCACA
Seq Logo
TGTGCAATAAAA
0 annotated groups

0 'de novo' group(s)
39037 1.08E-01 chr20:36,668,867-36,668,886 20  Seq Logo
mwkmwwysCGAmswCsCAkm
Seq Logo
kmTGwGswkTCGwrsskmsk
0 annotated groups

0 'de novo' group(s)
39064 7.03E-02 chr20:36,669,123-36,669,139 17  Seq Logo
yTAkGACACCTGsmrmw
Seq Logo
skykwCAGGTGTCmTAr
0 annotated groups

0 'de novo' group(s)
39097 1.59E-01 chr20:36,669,142-36,669,162 21  Seq Logo
mwsnryykTyGmGTTTG...
Seq Logo
kkrACAAACkCrAmrry...
0 annotated groups

1 'de novo' group(s)
352
39126 1.90E-02 chr20:36,669,164-36,669,174 11  Seq Logo
nGGGGCGknGn
Seq Logo
nCnmCGCCCCn
0 annotated groups

1 'de novo' group(s)
13355
39154 9.00E-02 chr20:36,669,253-36,669,271 19  Seq Logo
wGnAGAGGCGGCnGCnAGC
Seq Logo
GCTnGCnGCCGCCTCTnCs
0 annotated groups

0 'de novo' group(s)
39188 2.05E-01 chr20:36,669,278-36,669,287 10  Seq Logo
CrGCCGCATC
Seq Logo
GATGCGGCyG
0 annotated groups

1 'de novo' group(s)
13223
39222 1.89E-02 chr20:36,669,292-36,669,313 22  Seq Logo
AknnGGGGCGknrnyrA...
Seq Logo
wnnGCTyrnynmCGCCC...
0 annotated groups

0 'de novo' group(s)
39253 1.90E-02 chr20:36,669,418-36,669,429 12  Seq Logo
GGGCGGGnnGnr
Seq Logo
ynCnnCCCGCCC
0 annotated groups

0 'de novo' group(s)
39319 1.06E-01 chr20:36,669,431-36,669,447 17  Seq Logo
sCrGkTGTmmsyrsmsw
Seq Logo
swkwyrwkkACAmCyGw
0 annotated groups

0 'de novo' group(s)
39292 1.37E-03 chr20:36,669,432-36,669,439 8  Seq Logo
CAGGTGTC
Seq Logo
GACACCTG
0 annotated groups

0 'de novo' group(s)
39349 1.58E-01 chr20:36,669,448-36,669,457 10  Seq Logo
GAGGAGGGAG
Seq Logo
CTCCCTCCTC

Questions or comments: cisred@bcgsc.ca